Biofluid Mechanics Research Laboratory

Undergraduate Projects

Final Year Projects

In vitro hemodynamic investigation of Cava valves in an explanted pig heart model

This project aims to develop a pulsatile flow chamber which would capture the physiological environment of the heart. A porcine heart will be incorporated within this in-vitro experimental set-up and the chamber will be calibrated through the establishment of the physiological pressure waveforms within the Vena Cava. This set-up would then be manipulated so as to quantify the effectiveness of Ventricularization, to treat tricuspid regurgitation, based on the cardiac output.

Student: Karthic Anbalakan

Project Year: Aug 2014 - present

Supervisors: Dr Leo Hwa Liang

Computational study of blood flow characteristics in the left ventricle: a patient-specific study

Blood flow characteristics in the left ventricle is highly related to cardiac function. Hence a methodology to visualize patient specific left ventricle blood flow characteristics has an important diagnostic function. This project involves the design of a computational model of the human left ventricle based on patient specific data from MRI scans. The student will experience geometry reconstruction of the left ventricle as well as simulation of the change in shape of the left ventricle throughout a cardiac cycle. Blood flow parameters within the left ventricle such as flow velocity and pressure will then be evaluated and analyzed.

Student: Chong Jia Loon

Project Year: Aug 2011 - present

Supervisors: Dr Leo Hwa Liang, Dr Nguyen Vinh Tan

Mentor: Mr Kuan Yee Han

Development of a computational fluid dynamics methodology for analysing flow patterns in aneurysm with novel stent designs

In this project, a methodology for visualising flow patterns in abdominal aortic aneurysms is presented. The methodology comprises of the reconstruction of flow volume models from patient-specific images, the execution of computational fluid dynamics simulations, processing of the results as required, and the possible inclusion of stent design models into established simulation models. Two flow volume models were reconstructed from medical images for use in computational fluid dynamics simulations. This was accomplished primarily by using Materialise Mimics. The two three-dimensional models were based on images from the same patient before and after treatment for the aneurysm. After further refinement, static and transient simulations in ANSYS FLUENT were performed using both flow models. In the case of the transient simulations, pulsatile flow waveform data was used successfully. Additionally, the introduction of a stent design produced using Solidworks was attempted in the hope of use in further fluid dynamics simulations.

Student: Daryl Lin

Project Year: Aug 2010 - May 2011

Supervisors: Dr Leo Hwa Liang, Dr Benjamin Chua

Mentor: Mr Yeow Siang Lin

Development of an in vitro physiological fluidic set-up for assessment of vascular stenosis in hemodialysis patients

Vascular access stenosis remains to be the major cause of arteriovenous hemodialysis graft dysfunction, thus preemptive detection and localization of high risk stenotic lesion are crucial to to reduce the rate of access thrombosis. The aim of the project is to evaluate the potential of pressure-based parameters and detection indices for early detection of vascular access stenosis in the vascular access model (VAM). A hydraulic mock circulatory model of a brachial-antecubital (silicone-based) arteriovenous prosthetic graft that closely mimics the physiology was developed. Pressure profiles were measured at the arterial and venous hemodialysis needle. Varying degree of stenosis was generated at different anatomic locations in the VAM. It is observed that the combined usage of the Parterial line/MAP and Pvenous line /MAP indices, or the Pressure Ratio (PR) index would be useful for the detection of stenosis at different anatomic locations in the VAM by setting different threshold values. These stenosis detection indices possess promising diagnostic potential for early detection and localization of stenosis occuring in the VAM.

Student: Tan Hsiao Wei

Project Year: Aug 2010 - May 2011

Supervisors: Dr Leo Hwa Liang, Dr Benjamin Chua, Dr Victor Lee, Mr Teh Seng Khoon

Hemodynamics of a Stentless Pericardial Aortic Valve: Effects of coronary arteries on flows within Sinus of Valsava

Design and production of a silicone aortic model to include coronary arteries branching out at the sinus of Valsava, modification of an existing left heart simulation rig to house the new aortic model and relevant measurement apparatus, and the analysis of the flow dynamics near the aortic valve with the presence of coronary arteries using physical sensors.

Student: Yapp Jun Sem

Project Year: Aug 2010 - May 2011

Supervisors: Dr Leo Hwa Liang, Associate Professor Yeo Joon Hock (NTU School of Mechanical and Aerospace Engineering) Collaborators: Lau Yan Ling Jessica (NUS), Yeo Wei Zhong Alex (NTU)

To Develop an Artificial Abdominal Aortic Aneurysm Model as a Test Bedding System to Study the Effectiveness of a Newly Design Stent Graft

The purpose of this project is to design, fabricate and evaluate an artificial abdominal aortic aneurysm (AAA) part. Mimics and 3-Matic software were used to extract a three dimensional geometry of a AAA model from an actual patient�s medical images. A master mould of the AAA model was then fabricated. Using the master mould, other moulds were made which were later used to manufacture the artificial AAA part. The initial end product was evaluated and the manufacturing process was modified for subsequent fabrications so as to achieve an improved artificial AAA part. The procedure was repeated in order to obtain an acceptable AAA part that can be used in an in-vitro set-up of a human vascular system so as to study the effectiveness of a newly design stent graft for AAA cases.

Student: Azrul bin Azmi

Project Year: Aug 2010 - May 2011

Supervisors: Dr Leo Hwa Liang, Dr Benjamin Chua, Prof Teoh Swee Hin, Mr Yeow Siang Lin

Computation Study of Hemodynamics Performance of Bileaflet Mechanical Heart Valve

Patients with defective heart valve are usually treated with heart valve replacement therapy with bileaflet mechanical heart valve being most frequently used due to its durability. Despite bileaflet heart valve is able to function well, patients requires life-long anti-coagulation therapy after the heart valve replacement. Complications such as decreased half-life of platelet destruction, hemolysis and initiation of thrombus formation are shown to be associated with mechanical heart valve implantation, which result in ischemic attacks and strokes. On top of material properties and contact activation, hemodynamics performance and shear stress are believed to be the main causes for the complications. This project involves using a new simulation tool �openFoam� to simulate the flow through bileaflet mechanical heart valve in vivo.

Student: Chen Po-Yu

Project Year: Aug 2010 - May 2011

Supervisors: Dr Leo Hwa Liang, Dr Nguyen Vinh-Tan, Mr Kuan Yee Han

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