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Quantitative cellular description of gastric slow wave activity

Alberto Corrias & Martin L. Buist. Quantitative cellular description of gastric slow wave activity. Am J Physiol Gastrointest Liver Physiol, 294(4):G989–G995, Apr 2008.

This article presents a quantitative model of the cellular processes that lead to the generation of slow wave activity in the stomach. We provide the following implementations of the model:

  • A CellML file
  • A C++ implementation as a zip or tar.gz archive. The archives also contain a CodeBlocks project file for easy compilation of the code.
  • Matlab format [init & compute] as generated by COR);

Furthermore, we provide two additional CellML files, one where there is no IP3 release and with increased IP3 release. These two files can be used to reproduce the results published in the paper as shown in this page

A quantitative model of gastric smooth muscle cellular activation

Alberto Corrias & Martin L. Buist. A quantitative model of gastric smooth muscle cellular activation. Ann Biomed Eng, 35(9):1595–1607, September 2007.

This mathematical model defines a physiologically realistic quantitative description of smooth muscle cellular electrophysiology. We provide further data here in support of the above publication, primarily based on a CellML encoding of the model written by Alberto Corrias.

We provide the following implementations of the model:

  • A CellML file including simulation and graphing metadata;
  • A C++ implementation as a zip or tar.gz archive. The archives also contain a CodeBlocks project file for easy compilation of the code.
  • Matlab [init & compute generated from the CellML version using COR].

The above annotated CellML encoding of this model was used with the CellMLSimulator software to generate the graphical outputs from the model shown below. These results match those given in the paper and provide a useful validation check for the CellML encoding of the model. See this page for more details.

A quantitative model of human jejunal smooth muscle cell electrophysiology

Yong Cheng POH, Alberto CORRIAS, Nicholas CHENG and Martin BUIST. A Quantitative Model of Human Jejunal Smooth Muscle Cell Electrophysiology. PLoS ONE 7(8): e42385, 2012.

This study proposes a model of human jejunal smooth muscle cell electrophysiology. This is the first biophysically based model of an intestinal SMC, and the first model of a human GI cell. The resulting cellular description is able to reproduce experimentally recorded slow wave activity and produces realistic responses to a number of perturbations, providing a solid platform on which the causes of intestinal myopathies can be investigated.

Various implementations of the model were prepared by Yong Cheng and provided below:

To validate the CellML encoding of this model, COR was used to generate graphical outputs to compare against results given in the paper. See this page for details.