Cancer is one of the leading causes of death worldwide and is a disease that results from a rapid, unrestricted and uncontrolled proliferation of abnormal cells. It is also known to cause changes in the physical properties of cells. Typically, such physical property changes can result in several fold decreases in cell stiffness as well as cell-cell adhesion. These changes are significant and can lead to cancer metastasis, severe pathology and eventual catastrophic breakdown of the bodily functions. Using micro- and nanomechanical tools, we investigate the biomechanical changes occurring in cancer cells such as circulating tumor cells to obtain better understanding their contributions to metastasis. .
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