Name


Mrinal K Musib, PhD



Qualification


Ph.D  Biomedical Engineering

(Jointly by University of Texas Health Science Center,
San Antonio and University of Texas,
San Antonio), USA


Bachelor in Pharmacy
(Pharmaceutical Technology)



Appointment Status


2012 Lecturer,
Department of Bioengineering
2012 Consultant,
Johnson and Johnson,
Asia-pacific Region, Singapore
2009 - 2012 Post-doctoral Fellow,
State University of New York (SUNY),
Downstate Medical Center,
Brooklyn, New York


Department


Department of Biomedical Engineering



Contact


Email: biemkm@nus.edu.sg
Office: E1-05-24


Tel: +65-6601 3049
Fax: +65-6872 3069

Research Interests

  • Biomaterials (primarily for orthopaedic, cardiovascular and dental
    applications)
  • Medical devices (including regulations and quality/compliance)
  • Biological response to implant debris (primarily released by prosthetic
    devices and total joints)
  • Cell-(Nano)biomaterial interactions
  • Scaffolds as 3D matrices for drug release and for Tissue Engineering
    applications

Teaching Interests

  • GEK2505 Introductory Biomedical Engineering
  • BN4301 Principles of Tissue Engineering
  • BN4403 Cellular Bioengineering
  • Modules Taught AY 15/16
  • EG2401 Engineering Professionalism
  • BN2103 Bioengineering Design Workshop
  • BN3301 Introduction to Biomaterials
  • EG5911 Research Methodology & Ethics
  • BN5203 Advanced Tissue Engineering
  • BN5201 Advanced Biomaterials
  • BN5208 Regulatory & Bioethical Issues (Aug 16)
  • OTH347 and OTH531 (External modules) Regulation of Medical Devices, Quality and Compliance

Short Communications

  • Musib, M. Top Online Essays; “What is the most challenging ethical question facing young investigators in your field? How should it be addressed?” NextGen voices; Science; July 2014.

Awards/Scholarships

  • 2010 and 2011: Professional Development Scholarship, State University of New York,  Brooklyn, NY, USA
  • 2010: National Science Foundation (NSF) Fellowship to attend short course “Micro- and Nano- scale Phenomena in Tribology” San Diego, CA, USA
  • 2007: UTHSCSA grant to attend short course “Advances in Tissue Engineering”, Rice University, Houston, TX, USA
  • 2003- 2005: Graduate Fellowship, UTSA
  • 2005: Travel award, Biomedical Engineering Society Annual Fall Meeting, Baltimore, USA

Awards/Scholarships

  • NUS, Faculty of Engineering, Teaching Honors List 2015/2016

Educational Grants

  • "Adaptability and acceptability of the flipped classroom concept in an introductory multidisciplinary student setting", Teaching Enhancement Grant (TEG), CDTL, NUS, 2013.
  • "Teaching ethics by adopting a 'scenario-based learning' (SBL) approach using the 'flipped classroom' (FC) model: A Pilot study", Technology Enhanced Learning (TEL) grant, FoE, NUS, 2014.

Membership in Scientific/Professional Organization

  •  Golden Key International Honor Society
  •  Sigma Xi Honor Society
  •  Biomedical Engineering Society
  •  Orthopedic Research Society
  •  Society for Biomaterials
  • Member, Scientific Programme Committee, 7th WACBE World Congress on Bioengineering 2015
  • Organizing committee; 6th international conference on Ethical Issues in Biomedical Engineering, New York, 2011
  • Fellow, New York Academy of Sciences (NYAS), STEM mentoring program, NY, 2011
  • Peer advisor, Department of Biomedical Engineering, UTHSCSA ,2006-09
  • Reviewer, Journal of Orthopedics and Trauma
  • Reviewer, Journal of Long Term Effects of Medical Implants
  • Editorial Board Member, International Journal of Biological Engineering

Professional Service to Department and University

  • Graduate Studies Committee, Coursework (GSCC)
  • Member, departmental curriculum committee (DCC)
  • Member, department safety and resource management committee
  • Member, Industry attachment committee (IA)
  • Coordinator for departmental seminars for both graduate students and external visitors,
  • Co-ordinator for BME for the student exchange program (SEP).
  • Co-ordinator for approval of BN2001 (Independent study) as well as mapping of BN4109 (special topics in Bioengineering).
  • Co-ordinator, Lecturer and Program Advisory Committee (PAC) member for the new “Medical Device Regulatory Affairs (MDRA) Graduate Certificate Program”, which has been jointly launched by BME, NUS along with the Regulatory Affairs Professional Society (RAPS), USA.
  • Represented NUS in various outreach activities including University/Engineering open house and summer school teaching
  • Co-chair: ICBME conference December 2016, “Young Investigator Award” session

Graduate Dissertations examined/mentored:

  • Design of functional cationic copolymers as non-viral gene delivery vectors
  • Supramolecular biomaterials based on cyclodextrin-oligoethylenimine star polymers for drug and gene delivery
  • Cyclodextrin based polymeric supramolecular self-assembly system for anticancer therapeutics delivery
  • Physical responses of cells to grating topography via mechano-sensing
  • Biomechanical and Computational Investigation of Proximal Tibia Bone Grafting
  • Amphiphilic block copolymer enhancing biodegradable polymeric films for controlled protein delivery
  • Automating Ion Channel Model Development
  • Cyclodextrin-based Supramolecular Biomaterials for Drug Delivery

Final year projects supervised:

  • A new prosthesis design for Total Hip Replacement
  • Evaluation of the haemostatic properties of silk fibroin mesh
  • Control of silk hydrogel stiffness for musculoskeletal tissue engineering applications
  • Development of tunable matrix architectures for cell biology applications
  • Investigating the effect of macromolecular crowding on adult stem cell proliferation and adipogenesis
  • Stimuli-responsive hydrogel microcapsules for biomedical applications
  • Designing silk scaffold with porosity gradient to facilitate media flow and promote cellular ingrowth
  • Porous silk scaffold as a drug delivery agent for bone tissue engineering
  • Studying the size, dose and duration dependent effects of implant wear particles (including nanoparticles) on MSC's
  • Development of a customisable structure for finger splints
  • Fabricate and optimize the structure of the artificial hip/knee implant using the 3D printer
  • Biological response to orthopaedic wear debris nanoparticles
  • Cellular response to graded silk scaffolds
  • Development of an effective stem cells harvesting system using cord blood
  • Sustained release of antibiotic from silk scaffolds
  • Biological response to wear-particles released by artificial joints
  • Adipose stem cell (ASC) harvesting
  • Using 3D printer to fabricate medical devices
  • Stem cell expansion in a micro-carrier culture

Selected Publications

  1. Tay, A. & Musib, M. (2017) To MOOC or not to MOOC: A review of strategies to manage high attrition in MOOC participation. Asian Journal of the Scholarship of Teaching and Learning, 7(1), 67-82.
  2. Dewavrin JY, Muhammed A, Blocki A, Musib MK, Piazza F, Raghunath M. Synergistic Rate Boosting of Collagen Fibrillogenesis in Heterogeneous Mixtures of Crowding Agents, J. Phys. Chem. B, 2015, 119 (12), 4350–4358.
  3. Musib, MK Student perceptions of the impact of using the flipped classroom approach for an introductory-level multidisciplinary module. CDTL Brief, 17(2), 15-20. (2014).
  4. Musib, MK., Rasquinha, V., Saha, S. Comparison of modified acid, base and enzyme digestion techniques for isolation and characterization of orthopedic implant-debris nanoparticles. Am. J. Mater. Sc., 2(5), (2012).
  5. Musib, MK, Jones, J., Chakote, K., Hayes, W., Saha, S  Microhardness of Bi-Antibiotic Eluting Bone Cement Scaffolds. Progress in Biomaterials, 1:3 (2012).
  6. Musib, MK., Saha, S. Fractionation and Characterization of Particles Simulating Wear of Total Joint Replacements (TJR) Following ASTM Standards. J. Long Term Effects of Med. Implants, 21(1): 83-96 (2011).
  7. Musib, MK . Phagocytosis of Simulated Nano-wear Debris by Osteoblasts. Nanoscience and Nanotechnology, 1(1):1-6 (2011).
  8. Musib, MK. A Review of the History and Role of UHMWPE as a Component in Total Joint Replacements. Int. J. of Biological Engineering, 1(1):1-5, (2011).
  9. Musib, MK., Rasquinha, V., Saha, S. “Simultaneous Isolation and Characterization of Polymeric and Metallic Wear-debris Particles from Periprosthetic Tissues after total hip revision surgery J. Long Term Effects of Med. Implants, 21(4): 281–290 (2011).
  10. Musib, MK., Saha, S. “Nano-wear-particulates Elicit a Size and Dose Dependent Response by RAW 264.7 Cells”. SBEC, IFMBE publications. 32:158-160 (2010).
  11. Musib, MK., Saha, S. “Effect of Wear-debris Particles on RAW 264.7 Cells”. IEEE publication 36th Annual Northeast Bioengineering Conference, p.1-2, (2010).

Book Chapters

  1. Musib, MK., Saha, S. “Ethical Considerations in Biomaterials Research and Development”, (Invited), in New Materials and Technologies for Healthcare. (Editor: Hench L); Imperial College Press and World Scientific Publishing Company (2011).
  2. Musib, MK,, Saha, S. "Nanostructured Materials for Bone Tissue Replacement", (Invited) in Nanomedicine: Technologies and Applications. (Editor: Webster TJ); WoodHead Publishers, UK, 2012.

Invited Talks

  1. “Isolation and Characterization of UHMWPE nano-particles for MG63 osteoblast-like cell response studies”. Southwest Research Institute (SWRI), San Antonio, TX; March, (2009).
  2. “Isolation and Characterization of Ultra-high Molecular Weight Polyethylene (UHMWPE) Nanoparticles for Cell Response Studies”. BME speaker; SUNY Downstate Medical Ctr. and Polytechnic Institute of NYU Joint Biomedical Engineering (BME) Ph.D. Program. Brooklyn NY; May (2009).
  3. “Phagocytosis of UHMWPE particles by osteoblasts is dependent on particle size and associated with increased cell membrane destabilization and decreased differentiation”. Proceedings of the Orthopedic Research Society (ORS) Annual Meeting, New Orleans, LA, USA (2010).
  4. “Nano-wear-particulates elicit a size and dose dependent response by RAW 264.7 cells”. Proceedings of the 26th Southern Biomedical Engineering Conference (SBEC) Annual Meeting, Baltimore, MD, USA (2010).
  5. Towards a common “code of ethics” for Biomedical Engineers. Sixth International Conference of Ethical Issues in Biomedical Engineering, Polytechnic Institute of New York University, New York, (2011).April,2, 2011.
  6. “Biological Response to Orthopedic Wear-Debris Nano-particles”. Wichita State University, Kansas, April 27, 2011.
  7. “Response to Orthopedic Wear nanoparticles”. New York University, New York, September 19, 2011.
  8. “Cellular Response to Orthopedic Wear Nanoparticles and Biomechanical Studies on Bone Cement Scaffolds”. Singapore University of Technology and Design (SUTD), Singapore, December 7, 2011.
  9. “From Bench to Bed: The Journey of Biomaterials; Relevance of What We Learn in Classroom to a Fabricated Implant Device and Beyond”. National University of Singapore, Bioengineering, June 2012.
  10. “Student perceptions of the impact of using the flipped classroom approach for an introductory-level multidisciplinary module”, TEG talk, CDTL, NUS, Nov 2014.
  11. “Teaching Ethics by Adopting a Role Play, Scenario-based Learning Approach for an Authentic Learning Experience”, Teaching and Learning in Higher Education (TLHE), NUS, Dec, 2014.
  12. ICAMET 2014, Biological response to orthopaedic wear-debris nanoparticles, ICAMET Dec 2014, Shibpur, Kolkata, India.
  13. Technology driven pedagogical techniques incorporating a novel and effective “scenario-based, flipped learning approach” for an authentic learning experience; Ascilite Annual conference, Nov 2015.
  14. Why some medical devices fail, while others don’t: identifying and understanding some root causes and how we can prevent such failures, Invited talk for the “Challenges in product developments of medical implants and devices”, Dec 18-19, 2015, IIEST Shibpur
  15. Technology Enhanced Learning (TEL) Workshop, “Integrating Innovative and Technology Driven Pedagogical Techniques to Impart Authentic and Life Long Learning”; 20th September, 2016

Conference Presentations and Abstracts

  1. Musib, MK. "Technology-Driven Novel Pedagogical Technique Incorporating a "Scenario-based, Flipped Learning Approach" for an Authentic Learning Experience". Tenth International Conference on e-Learning and Innovative Pedagogies, University of Toronto, Canada (2017).
  2. Musib, MK. et al. “A novel molecule “Lubricin” is involved in the “Temporo mandibular Joint Disorders”. Proceedings of the 2005 BMES Annual Fall Meeting, Baltimore, USA. (2005).
  3. Dean, D., Musib, MK. et al. “Metabolites of 5-Lipoxygenase are Involved in Osteoblast Response to Implant Surface Roughness”. Proceedings of the 2007 BMES Annual Fall Meeting, Los Angeles, CA, USA, (2007).
  4. Musib, MK et al. “Isolation of UHMWPE nano particles using vacuum filtration and optimized solvent conditions”. Proceedings of the 2008 Biomedical Engineering Society (BMES) Annual Meeting, St. Louis, MO, USA (2008).
  5. Musib, MK. et al. “Fractionation of UHMWPE Particles into Micron-, Subicron-, and Nano- Fractions and Initial Assessment of Osteoblast Response to Particle Size”. Proceedings of the Orthopedic Research Society (ORS) Annual Meeting, Las Vegas, NV, USA (2009).
  6. Musib, MK. et al. “Effect of UHMWPE nanoparticles on Human Osteoblast Proliferation and Viability”. Proceedings of the American Orthopaedic Association (AOA) Annual Meeting, Florida, USA (2009) (Special Emphasis Poster).
  7. Musib, MK. et al. “Treatment of  MG63 Cells With UHMWPE Particles After Fractionation Into Three Different Size Ranges, Including a Nanometer Size Fraction”. Proceedings of the Society for Biomaterials (SFB) Annual Meeting, San Antonio, TX, (2009).
  8. Musib, MK., Saha, S. “Effect of wear-debris particles on RAW 264.7 Cells”. Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, Columbia University, New York, USA (2010) p.37.
  9. Musib, MK., Rasquinha, V., Saha, S. “Characterization of wear particles from periprosthetic tissues from total hip patients”. Proceedings of the Society for Biomaterials (SFB) Annual Meeting, Seattle, WA, 2010.
  10. Marshall, A., Musib, MK. et al. “Effect of UHMWPE particles on Mesenchymal Stem Cell Replication.” Proceedings of the American Association of Orthopedic Surgeons (AAOS) Annual Meeting, New Orleans, LA, USA (2010) p.107.
  11. Musib, MK., Rasquinha, V., Saha, S. “Orthopedic implant wear debris elicit a size-dose dependent  response by cells”. Proceedings of the American Association of Orthopedic Surgeons (AAOS) Annual Meeting, San Diego, CA, USA (2011), P.019.
  12. Musib, MK., Saha, S. “Response of RAW 264.7 cells to simulated wear-debris nanoparticulates”. Proceedings of the Orthopedic Research Society (ORS) Annual Meeting, Long Beach, California, CA, USA (2011). P.1101.
  13. Musib, MK. et al. “Deterioration of Compressive Properties of Bone Cement due to Release of Multiple Antibiotics over Extended Time Periods”. Proceedings of the Society for Biomaterials (SFB) Annual Meeting, Orlando, FL, 2011. P 797.
  14. Musib, MK., Urban, W., Saha, S. Towards a common “code of ethics” for Biomedical Engineers. Sixth International Conference on Ethical Issues in Biomedical Engineering, Polytechnic Institute of New York University, New York, (2011).
  15. Musib, MK., Rasquinha, V., Saha, S. “Characterization and Quantification of Wear-debris from Periprosthetic Tissues from Total Hip Patients”. Proceedings of the Society for Biomaterials (SFB) Annual Meeting, Orlando, FL, 2011. P 770.
  16. Musib, MK et al. Compressive Properties of PMMA due to Release of Multiple Antibiotics over Extended Time Periods. Proceedings of the Biomedical Engineering Society (BMES) Annual Meeting, Hardford, CT, 2011. P 142.
  17. Musib, MK. et al. Effect of Addition of high Dose Antibiotics on the Mechanical Properties of Bone Cement: A Preliminary Study. Proceedings of the Orthopedic Research Society (ORS) Annual Meeting, San Francisco, California, CA, USA (2012). P.643.
  18. Feuer, G., Musib MK., et al. “Biomechanical Evaluation of Osteoporotic Sheep Long Bones”. Proceedings of the 29th Annual Southern Biomedical Engineering Conference, Miami, FL, USA (2013).

Educational Grants

  1. "Technology-Driven Novel Pedagogical Technique Incorporating a "Scenario-based, Flipped Learning Approach" for an Authentic Learning Experience". Technology Enhanced Learning (TEL) Conference Grant, FoE, NUS, 2017