Name

 

Toh Siew Lok            

 

Qualification

 

B.Sc. (Mech. Engrg), Hons. University of Strathclyde, U.K. (1974)
Ph.D (Mech Engrg) University of Strathclyde, U.K. (1980)


 

Appointment Status

 

Adjunct Associate Professor

 

Department

 

Department of Biomedical Engineering

 

Contact

 

.Email: bietohsl@nus.edu.sg

Tel Office: +(65) 6516 2920

Fax:            +(65) 6872 3069

Lab Website: http://www.bioeng.nus.edu.sg/trl/default.htm

 

Research Interests

Experimental Mechanics, Biomechanics, Functional Tissue Engineering

Research Projects


1. Design and development of bioreactor for in-vitro fabrication of biological ligament device using tissue engineering approach (PI)

2. Tissue engineering approaches to the repair and regeneration of anterior cruciate ligament (PI)

3. Mechanical Characterisation of Bulk Soft Tissue for Intelligent CAD-FEA Prosthetics Application: Combining in-vivo Experiments and Finite Element Modelling (PI)

4. Advanced bioreactor system for tendon/ligament regeneration (PI)

5. Use of Silk as Novel Scaffold Material For Ligament/Tendon Tissue Engineering (PI)

6. Interfacial Tissue Engineering for Tendon and Ligament Regeneration Using Bone Marrow Stromal
Cells on Novel 2-D Scaffolds (PI)

7. Tissue engineering approaches to the repair and regeneration of anterior cruciate ligament (Co-PI)

8. Tri--phasic silk/stem cell-based bone-ligament-bone construct in the repair of medial collateral ligament in rabbits (Co-PI)

9. Development of a functional tissue engineered bone-ligament-bone graft with novel fixation device to bone tunnel for ACL reconstruction (Co-PI)

10. The Development of an In Vitro 3D Tumor Model for Drug Testing Studies (Co-PI)

11. Tissue Engineering of the Intervertebral Disc (IVD) - Regenerating the Annulus Fibrosus (AF) with Electrospinning and Physiologically Mimetic Culture (PI)

 

 

Teaching

1. BN2203-Introduction to Bioengineering Design

2. BN3101-Biomedical Engineering Design

3. BN3201-Introduction to Biomechanics

4. ME4212-Aircraft Structures

 

 

Service to University

 

(a) Deputy Head, Dept of Bioengineering in charge of education and student affairs.
(b) Chairman, Curriculum Committee, Dept of Bioengineering.
(c) Member, Search Committee, Dept of Bioengineering;
(d) Member, Department Management Committee, Dept of Bioengineering;

At Faculty Level:

(a) EUPAC Member
(b) Member, Faculty of Engineering EAB Committee

At University Level:

(a) Management Board Member, NUS Tissue Engineering Program

 

 

Membership in Scientific/Professional Organization

 

1. Member, Institution of Mechanical Engineers United Kingdom

2. Member, American Society of Mechanical Engineers, United States of America

3. Member, Institution of Engineers, Singapore

4. Member, Steering Committee of Asian Committee for Experimental Mechanics

5. Secretary of the International Federation for Medical and Biological Engineering (IFMBE) Working     Group for Asia-Pacific Activities

6. Member of the the International Federation for Medical and Biological Engineering (IFMBE) Awards     Committee

 

 

Selected Publications


1
Liu H, Ge Z, Wang Y, Toh SL, Sutthikhum V, Goh JC. Modification of sericin-free silk fibers for ligament tissue engineering application. Journal of biomedical materials research Part B, Applied biomaterials. 2007;82:129-38.
2
Fan H, Liu H, Toh SL, Goh JC. Enhanced differentiation of mesenchymal stem cells co-cultured with ligament fibroblasts on gelatin/silk fibroin hybrid scaffold. Biomaterials. 2008;29:1017-27.
3
Fan H, Liu H, Wang Y, Toh SL, Goh JC. Development of a silk cable-reinforced gelatin/silk fibroin hybrid scaffold for ligament tissue engineering. Cell transplantation. 2008;17:1389-401.
4
Fan H, Liu H, Wong EJ, Toh SL, Goh JC. In vivo study of anterior cruciate ligament regeneration using mesenchymal stem cells and silk scaffold. Biomaterials. 2008;29:3324-37.
5
Liu H, Fan H, Toh SL, Goh JC. A comparison of rabbit mesenchymal stem cells and anterior cruciate ligament fibroblasts responses on combined silk scaffolds. Biomaterials. 2008;29:1443-53.
6
Liu H, Fan H, Wang Y, Toh SL, Goh JC. The interaction between a combined knitted silk scaffold and microporous silk sponge with human mesenchymal stem cells for ligament tissue engineering. Biomaterials. 2008;29:662-74.
7
See EY, Toh SL, Goh JC. Technique to accurately quantify collagen content in hyperconfluent cell culture. Journal of molecular histology. 2008;39:643-7.
8
Fan H, Liu H, Toh SL, Goh JC. Anterior cruciate ligament regeneration using mesenchymal stem cells and silk scaffold in large animal model. Biomaterials. 2009;30:4967-77.
9
Nayak BP, Goh JC, Toh SL, Satpathy GR. In vitro study of stem cell communication via gap junctions for fibrocartilage regeneration at entheses. Regenerative medicine. 2010;5:221-9.
10
Sahoo S, Ang LT, Cho-Hong Goh J, Toh SL. Bioactive nanofibers for fibroblastic differentiation of mesenchymal precursor cells for ligament/tendon tissue engineering applications. Differentiation; research in biological diversity. 2010;79:102-10.
11
Sahoo S, Ang LT, Goh JC, Toh SL. Growth factor delivery through electrospun nanofibers in scaffolds for tissue engineering applications. Journal of biomedical materials research Part A. 2010;93:1539-50.
12
Sahoo S, Lee WC, Goh JC, Toh SL. Bio-electrospraying: A potentially safe technique for delivering progenitor cells. Biotechnology and bioengineering. 2010;106:690-8.
13
Sahoo S, Toh SL, Goh JC. PLGA nanofiber-coated silk microfibrous scaffold for connective tissue engineering. Journal of biomedical materials research Part B, Applied biomaterials. 2010;95:19-28.
14
Sahoo S, Toh SL, Goh JC. A bFGF-releasing silk/PLGA-based biohybrid scaffold for ligament/tendon tissue engineering using mesenchymal progenitor cells. Biomaterials. 2010;31:2990-8.
15
See EY, Toh SL, Goh JC. Multilineage potential of bone-marrow-derived mesenchymal stem cell cell sheets: implications for tissue engineering. Tissue engineering Part A. 2010;16:1421-31.
16
Teh TK, Toh SL, Goh JC. Optimization of the silk scaffold sericin removal process for retention of silk fibroin protein structure and mechanical properties. Biomed Mater. 2010;5:035008.
17
mSahoo S, Teh T, He P, Toh SL, Goh J. Interface tissue engineering: next phase in musculoskeletal tissue repair. Annals of the Academy of Medicine, Singapore. 2011;40:245-51.
18
See EY, Toh SL, Goh JC. Effects of radial compression on a novel simulated intervertebral disc-like assembly using bone marrow-derived mesenchymal stem cell cell-sheets for annulus fibrosus regeneration. Spine. 2011;36:1744-51.
19
See EY, Toh SL, Goh JC. Simulated intervertebral disc-like assembly using bone marrow-derived mesenchymal stem cell sheets and silk scaffolds for annulus fibrosus regeneration. Journal of tissue engineering and regenerative medicine. 2011.
20
Tan PH, Aung KZ, Toh SL, Goh JC, Nathan SS. Three-dimensional porous silk tumor constructs in the approximation of in vivo osteosarcoma physiology. Biomaterials. 2011;32:6131-7.
21
Teh TK, Toh SL, Goh JC. Aligned hybrid silk scaffold for enhanced differentiation of mesenchymal stem cells into ligament fibroblasts. Tissue engineering Part C, Methods. 2011;17:687-703.
22
Chen K, Sahoo S, He P, Ng KS, Toh SL, Goh JC. A Hybrid Silk/RADA-Based Fibrous Scaffold with Triple Hierarchy for Ligament Regeneration. Tissue engineering Part A. 2012.
23
Chen K, Teh TK, Ravi S, Toh SL, Goh JC. Osteochondral Interface Generation by Rabbit Bone Marrow Stromal Cells and Osteoblasts Co-culture. Tissue engineering Part A. 2012.