Dr. CHEN Nanguang

Professional Work Experience



Jan 2002 - Aug 2004

   Assistant Research Professor, Department of Electrical    and Computer Engineering, University of Connecticut

Feb 2000 - Dec 2001

 Postdoctoral Fellow, Department of Electrical and    Computer  Engineering, University of Connecticut

1994 - 1997

 Lecturer, Department of Physics, Hunan Normal   University

1988 - 1991

  Instrumentation Engineer, Hunan Detergent Factory



Appointment Status:

Associate Professor




Department of Biomedical Engineering






Tel: +(65) 6516-4401
Fax: +(65) 6872-3069

Laboratory Site:


Research Interests

Biomedical Optical Imaging including Diffuse Optical Tomography, Optical Coherence Tomography, and Focal Modulation Microscopy


Research Projects

NRF: PI, “Line-scan focal modulation microscopy,” 2010-2011 (S$220,300)

SBIC-SSCC/A*STAR, PI, “Novel insight into basic problems of stem cell biology through live imaging of neuronal stem cells using Focal Modulation Microscopy,” 2008-2011 (S$1.2M).

SERC/A*STAR: PI, “Pseudo-random single photon counting for time-resolved optical spectroscopy and imaging,” 2006-2009 (S$635,140).

FRC/NUS: PI, “Real-Time In Vitro Dual-Mode Imaging for Tissue Engineering,” 2005-2008 (S$82,500).

OLS/NUS: PI, “Optical Mammography for Breast Cancer Early Detection,” 2005-2008 (S$200,000).


Membership in Scientific/Professional Organizationion

Society of Photo-Optical Instrumentation Engineers (SPIE) 
Optical Society of America (OSA)


Selected Publications


Book Chapter:

Molecular Imaging,  ISBN: 978-953-51-0359-2

Focal Modulation Microscopy: Principle and Techniques
By Nanguang Chen, Guangjun Gao and Shau Poh Chong

Journal Papers:


[1]  M. Sun and N. G. Chen, “Non-invasive measurement of blood glucose level by time-resolved transmission spectroscopy: A feasibility study,” Opt. Commun.011), 


[2]  K. Si, W. Gong, N. G. Chen, and C. J. R. Sheppard, “Two-photon focal modulation microscopy in turbid media,” Appl. Phys. Lett. 99, 233702 (2011); doi: 10.1063/1.3665936

[3]  K. Mehta and N. G. Chen, “Plasmonic chiral contrast agents for optical coherence tomography,” Optics Express 19 (16), 14903 - 14912 (2011).

[4]  G. Gao, S. P. Chong, C. J. R. Sheppard, N. G. Chen, “Considerations of aperture configuration in focal modulation microscopy from the standpoint of modulation depth,” Journal of the Optical Society of America A 28 (4), 496-501 (2011).

[5]  L. Chen and N. G. Chen, “Optimization of Source and Detector Configurations Based on Cramer-Rao Lower Bound Analysis,” Journal of Biomedical Optics 16 (3), 035001 (2011).

[6]  K. Si, W. Gong, N. G. Chen, and C. J. R. Sheppard, “Enhanced background rejection in thick tissue using focal modulation microscopy with quadrant apertures,”Optics Communications 284 (5), 1475-1480 (2011).

[7]  S. P. Chong, C. H. Wong, K. F. Wong, C. J. R. Sheppard, and N. G. Chen, “High-speed focal modulation microscopy using acousto-optical modulators,”Biomedical Optics Express 1 (3), 1026-1033 (2010).

[8]  Q. Zhang, L. Chen, and N. G. Chen, “Pseudo-random single photon counting: a high-speed implementation,” Biomedical Optics Express 1 (1), 41-46 (2010).

[9]  S. P. Chong, C. H. Wong, C. J. R. Sheppard, and N. G. Chen, “Focal Modulation Microscopy: A Theoretical Study,” Optics Letters 35 (11), 1804-1806 (2010).

[10] W. Gong1, K. Si, N. G. Chen, and C. J. R. Sheppard, “Focal modulation microscopy with annular apertures: A numerical study,” Journal of Biophotonics 3 (7), 476-484 (2010).

[11]  W. Mo and N. G. Chen, “Design of Advanced Time-Domain Diffuse Optical Tomography System,” IEEE Journal of Selected Topics in Quantum Electronics 16 (3), 581-587 (2010).

[12]  Y. Xu, J. Singh, and N. G. Chen, “Large rotation angle micromirror based on ypocycloidal electrothermal actuators,” Electronics Letters 46 (10) 704-706 (2010).

[13]  H. T. Tian, F. Shakith, H. W. Soon, Q. Zhang, C. Zhang, Y. Ha and N. G. Chen, “Ultra Storage Efficient Time Digitizer for Pseudo Random Single Photon Counter Implemented on Field Programmable Gate Array,” IEEE Transactions on Biomedical Circuits and Systems 4 (1), 1-10 (2010).

[14]  K. Agarwa, L. Chen, N. G. Chen, and X. Chen, “Multistage Inversion Algorithm for Biological Tissue Imaging,” Journal of Biomedical Optics 15 (1), 016007 (2010).

[15]  Y. Xu, M. F. Wang, C. S. Premachandran, K. W. S. Chen, N. G. Chen and M. Olivo, “Platinum microheater integrated silicon optical bench assembly for endoscopic optical coherence tomography,” Journal of Micromechanics and Microengineering 20 (2010), 015008 (8pp).

[16]  K. Si, W. Gong, N. G. Chen, C. J. R. Sheppard, “Edge enhancement for in-phase focal modulation microscope,” Applied Optics 48 (32), 6290-6295 (2009).

[17]  W. Gong, K. Si, N. G. Chen, C. J. R. Sheppard, “Improved spatial resolution in fluorescence focal modulation microscopy,” Optics letters 34 (22), 3508-3510 (2009).

[18]  W. Mo, T. Chan, L. Chen, and N. G. Chen, “Quantitative characterization of optical and physiological parameters in normal breasts using time-resolved spectroscopy: in-vivo results of 19 Singapore women,” Journal Biomedical Optics 14 (6), 064004 (2009).

[19]  C. H. Wong, S. P. Chong, C. J. R. Sheppard, and N. G. Chen, “Simple spatial phase modulator for focal modulation microscopy,” Applied Optics 48 (17), 3238-3243 (2009).

[20]   E. L. Lim, J. Teng, S. S. Ang; J. Dong, S. Chua,  K. Shanmugasundaram, and N. G. Chen, “The near-diffraction limited operation of submicron-ridge laser arrays,”IEEE Journal of Quantum Electronics 45 (8), 893-903 (2009).

[21]  C. S. Premachandran, A. Khairyanto, K. Chen, J. Singh, J. Teo, Y. XU, N. G. Chen, C. J. R. Sheppard, and M. Olive, “Design, Fabrication, and Assembly of an Optical Biosensor Probe Package for OCT (Optical Coherence Tomography) Application,” IEEE Transactions on Advanced Packaging 32 (2), 417-422 (2009).

[22]  Y. Xu, J. Singh, S. Thevapriya and N. G. Chen, “Two-axis gimbal less electrothermal micromirror for large angle circumferential scanning,” IEEE Journal of Selected Topics in Quantum Electronics 15 (5), 1432-1438 (2009).

[23]  J. Cheng, Y. Zhang, P. Gopalakrishnakone and N. G. Chen, “Use of the Upside-Down Method to Prepare Porous Polymer Films with Tunable Surface Pore Sizes,”Langmuir 25 (1), 51 - 54 (2009).

[24]  N. G. Chen, C. H. Wong and C. J. R. Sheppard, “Focal Modulation Microscopy,” Optics Express 16 (23), 18764-18769 (2008).

[25]  Y. Xu, J. Singh, C. S. Premachandran, A. Khairyanto, K. W. S. Chen, N. G. Chen, C. J. R. Sheppard and M. Olivo, “Design and development of a 3D scanning MEMS OCT probe using a novel SiOB package assembly,” Journal of Micromechanics and Microengineering 18 125005 (2008).

[26]  W. Mo and N. G. Chen, “Fast time domain diffuse optical tomography using pseudorandom bit sequences,” Optics Express 16 (18), 13643-13650 (2008).

[27]  Q. Zhang, H. W. Soon, H. T. Tian, S. D. Fernando, Y. Ha and N. G. Chen, “Pseudo Random Single Photon Counting for Time Resolved Optical Measurement,”Optics Express 16 (17), 13233-13239 (2008).

[28]  L. LIU, F. Diaz, L. Wang, B. Loiseaux, J. Huignard, C. J. R. SHEPPARD and N. G. Chen, "Super-resolution along extended depth of focus with binary-phase filters for Gaussian beam". Journal of the Optical Society of America A - Optics Image Science and Vision 25 (8), 2095-2101 (2008).

[29] J. Singh, J. H. S. Teo, Y. Xu, C. S. Premachandran, N. G. Chen, R. Kotlanka, M. Olive and C. J. R. SHEPPARD, "A two axes scanning SOI MEMS micromirrorfor
endoscopic bioimaging". Journal of Micromechanics and Microengineering 18, 025001(2008).

[30]  X. Song, D. Wang, N. G. Chen, J. Bai, and H. Wang, “Reconstruction for free-space fluorescence tomography using a novel hybrid adaptive finite element algorithm,”Optics Express 15 (26), 18300-18317 (2007).

[31]  L. Liu, C. J. R. Sheppard, and N. G. Chen, “Double-reflection polygon mirror for high-speed optical coherence microscopy,” Optics Letters 32, 3528-3530 (2007).

[32]  L. Liu, C. Liu, C. H. Wong, C. J. R. Sheppard, and N. G. Chen, “Binary-phase spatial filter for real-time swept source optical coherence microscopy,” Optics Letters 32, 2375-2377 (2007).

[33]  Y. Xu, J. Singh, C. J. R. Sheppard, and N. G. Chen, “Ultra long high resolution beam by multi-zone rotationally symmetrical complex pupil filter,” Optics Express 15 (10), 6409-6413 (2007)

[34]  N. G. Chen, “Controlled Monte Carlo method for light propagation in tissue of semi-infinite geometry,” Applied Optics 46 (10), 1597-1603 (2007).

[35]  C. Liu, N. G. Chen, and C. Sheppard, “Nano-illumination based on self-imaging inside the sub-wavelength metallic slit,” Applied Physics Letters 90 (1), Art. No. 011501 (2007).

See the full publication list in my group websie: