Dieter TRAU

  • Associate Professor

2001 Ph.D. in Chemistry, HKUST, Hong Kong in collaboration with the Max-Planck Institute for Colloids and Interfaces, Germany.
1994 Master (Dipl. Ing. FH) in Chemical Engineering/Biotechnology, Aachen University of Applied Science, Germany.

Research Interest

Bioanalytical Chemistry, Microarrays, Biosensors

Technopreneurship & Startups

Serial entrepreneur since 2004. At NUS, developed an idea into a full scale startup company AYOXXA (www.ayoxxa.com) which now employs 25 people and closed its Series A and B venture funding round over a total of 20 million S$. AYOXXA won several prizes and operates research offices in Singapore and Germany. Previous to NUS cofounded the biotechnology companies’ biognostic AG (www.biognostic.de) in Berlin, XanTec (www.xantec.com) in Germany.

Inventor of 13 patent families resulting in more than 70 patent applications of which 20 are granted and commercialized by different companies. He is also a co-inventor of Capsulution AG (Berlin, Germany) nano-and microencapsulation technology and drug delivery platform and for Supernova Ltd (Hong Kong) biolabeling technology. Dr Trau has extensive knowledge and experience in IP management including IP search, patent drafting, patent strategy, novelty and inventive step issues and patent licensing and commercialization.

Selected Journal Publications

  1. Kantak C., Beyer S., Bansal T*, Trau D.*, Utilizing microfluidics to synthesize polyethylene glycol microbeads for Förster resonance energy transfer based glucose sensing,  Biomicrofluidics , 2012.Article featured in AIP "American Institute of Physics News Room".
  2. Bai J., Beyer S., Toh S.Y., Trau D.*, Self-Assembly of Polyamines as a Facile Approach to Fabricate Permeability Tunable Polymeric Shells for Biomolecular Encapsulation, ACS Appl. Mater. Interfaces3(5), 1665-1674, 2011 (Impact factor not assigned)
  3. Kantak C., Beyer S., Yobas L., Bansal T., Trau D.*, A ‘microfluidic pinball’ for on-chip generation of Layer-by-Layer polyelectrolyte microcapsules, Lab-on-a-Chip, 11, 1030-1035, 2011  (Impact factor 6.5).Article featured in RSC Chemistry World . See videos here  http://pubs.rsc.org/en/Content/ArticleLanding/2011/LC/c0lc00381f
  4. Wang C., Trau D.* ,Portable Generic DNA Bioassay System based on in situ Oligonucleotide Synthesis and Hybridization Detection Biosensors & Bioelectronics, 26(5) 2436-2441, 2010  (Impact factor 5.4) 
  5. Lin L., Beyer S., Wohland T., Trau D.*, Lubrich D.*, Surface-Bound Micro-Enclosures for Biomolecules Angewandte Chemie Int. Ed.,  49(50) 9773-9776, 2010   (Impact factor 11.8)
  6. German Edition: Lin L., Beyer S., Wohland T., Trau D.*, Lubrich D.*, Oberflächengebundene Mikrobehälter zum Einschluss und zur Untersuchung von Biomolekülen Angewandte Chemie German Ed.,  122(50) 9967, 2010
  7. Bai J, Beyer S, Mak W.C, Rajagopalan R., Trau D.* Inwards build up of concentric polymer layers: A Method for Biomolecule Encapsulation and Microcapsule Encoding,  Angewandte Chemie Int. Ed. 49, 5189-5193, 2010  (Impact factor 11.8)
  8. German Edition: Bai J, Beyer S, Mak W.C, Rajagopalan R., Trau D.* Nach innen gerichteter Aufbau konzentrischer Polymerschichten: eine Methode zur Verkapselung von Biomolekülen mit simultaner Kodierung,  Angewandte Chemie, 122, 5316-5320, 2010  (Impact factor 10)
  9. Bai J.,  Beyer S., Mak W. C., Trau D.*; Fabrication of Inflated LbL Microcapsules with a “Bead-in-a-Capsule” Morphology by Osmotic Pressure Driven Inflation of Capsular Wall,  Soft Matter, (5) 4152-4160, 2009  (Impact factor 4.6) 
  10. Mak W. C.*; Bai J., Chang  X.Y., Trau D.*, Matrix Assisted Colloidosome Reverse-Phase Layer-by-Layer - Encapsulating Biomolecules in Hydrogel Microcapsules with Extremely High Efficiency and Retention Stability,  Langmuir, 25 (2), 769-775, 2009  (Impact factor 4.1) 
  11. Zhang L., Tan Cherng-Wen, Roy P., Trau D.*, In-situ Measurement of Cellular Microenvironments in a Microfluidic Device,  Lab-on-a-Chip, 9(2), 257-262, 2009,  (Impact factor 6.5) 
  12. Mak W.C., Cheung K.Y., Trau D.*, Diffusion Controlled and Temperature Stable Microcapsule Reaction Compartments for High Throughput Microcapsule-PCR,  Advanced Functional Materials, 18(19), 2930 - 2937, 2008, (Impact factor 7.5)
  13. Mak W.C., Cheung K.Y., Trau D.*, The Influence of Different Polyelectrolytes on Layer-by-Layer Microcapsules Properties Encapsulation Efficiency, Colloidal and Temperature Stability,  Chemistry of Materials, 20(17), 5475-5484, 2008  (Impact factor 5.4)
  14. Jiang J., Li X., Mak W.C., Trau D*,Integrated Direct DNA/Protein Patterning and Microfabrication by Focused Ion Beam Milling,  Advanced Materials, 20(9), 1636-1643, 2008  (Impact factor 8.4)
  15. Beyer S., Mak W.C., Trau D.*, Reverse-Phase LbL-Encapsulation of Highly Water Soluble Materials by Layer-by-Layer Polyelectrolyte Self-Assembly,  Langmuir, 23(17), 8827-8832, 2007  (Impact factor 4.1) 
  16. Trau D.*, Jiang J., Sucher J.N., Preservation of the Biofunctionality of DNA and Protein during Microfabrication,  Langmuir, 22(3), 877-881, 2006  (Impact factor 4.1) 
  17. Mak W.C.*, Cheung K.J., Trau D., Warsinke A., Scheller F., Renneberg R., Electrochemical Bioassay Utilizing Encapsulated Electrochemical Active Microcrystal Biolabels,  Analytical Chemistry77(9), 2835-2841, 2005  (Impact factor 5.3) 
  18. Chan C.P., Bruemmel Y., Seydack M., Sin K.K., Wong L.W., Merisko-Liversidge E., Trau D., Renneberg R.*, Nanocrystal Biolabels with Releasable Fluorophores for Immunoassays,  Analytical Chemistry, 76(13), 3638-3645, 2004  (Impact factor 5.3) 
  19. Mak W.C., Li Y., Lau K.L., Trau D.*, Nanoengineered Encapsulation of Mediator Microcrystals and there use as a Non-metallic Label System for the Silver Enhancement technique,  Electroanalysis, 16(1-2), 156-160, 2004  (Impact factor 2.9) 
  20. Trau D.*, Renneberg R., Encapsulation of glucose oxidase microparticles within a nanoscale layer-by-layer film: immobilization and biosensor applications, Biosensors & Bioelectronics, 18(12), 1491-1499, 2003 (Impact factor 5.1)
  21. Cheung M.K.L, Trau D., Yeung K.L., Carles M., Sucher J.N.*, 5'-Thiolated Oligonucleotides on (3-mercaptopropyl) trimethoxysilane-Mica: Surface Topography and Coverage,  Langmuir, 19(14), 5846-5850, 2003  (Impact factor 4.0)
  22. Trau D.*, Yang W., Lehmann M., Caruso F., Yu N.T., Renneberg R., Nanoencapsulated Microcrystalline Particles for Superamplified Bioassays,  Analytical Chemistry, 74(21), 5480-5486, 2002  (Impact factor 5.3) 
  23. Lao A.I.K., Trau D., Hsing I.M.*, Miniaturized Flow Fractionation Device Assisted by a Pulsed Electrical Field for Microparticle Separation,  Analytical Chemistry, 74(20), 5364 -5369, 2002  (Impact factor 5.3)
  24. Trau D., Lee T.M.H., Lao A.I.K., Lenigk R., Hsing I.M., Ip N.Y., Carles M.C., Sucher J.N.*, Genotyping on a complementary metal oxide semiconductor silicon polymerase chain reaction chip with integrated DNA microarray ,  Analytical Chemistry , 74(13), 3168-3173, 2002  (Impact factor 5.3) 
  25. Caruso F. *, Yang W., Trau D., Renneberg R., Microencapsulation of Uncharged Low Molecular Weight Organic Materials by Polyelectrolyte Multilayer Self-Assembly,  Langmuir, 16(23); 8932-8936, 2000 (Impact factor 4.0)
  26. Caruso F.*, Trau D., Möhwald H., Renneberg R., Enzyme Encapsulation in Layer-by-Layer Engineered Multilayer Capsules;  Langmuir, 16(4), 1485-1488, 2000  (Impact factor 4.0) 
  27. Schult K., Katerkamp A., Trau, D., Grawe F., Cammann K., Meusel M.*, Disposable Optical Sensor Chip for Medical Diagnostics: New Ways in Bioanalysis,  Analytical Chemistry; 71(23), 5430-5435, 1999 (Impact factor 5.3)