The Optical Bioimaigng Laboratory have been developing novel optical imaging and spectroscopy methods for biomedical applications. An in-vivo fluorescence imaging method, focal modulation microscopy, has been invented and licensed to a global leader in microscopy. High performance diffuse optical tomography has been actively developed for optical mammography and brain imaging. We are also interested in designing and fabrication of nanostructures as new optical imaging contrast agent, especially for molecular imaging with optical coherence tomography.
Our work can be summarized into three major areas:
Functional Computational Anatomy Lab
Computational Functional Anatomy (CFA) is the mathematical study of anatomical configurations and signals associated with anatomy and functions in anatomical coordinates using multi-modal images. Its ultimate goal is to identify image biomarkers associated with a specific disease.
Currently, most of our work focuses on the development of medical image analysis tools to assess anatomical shape and functions of the human brain in magnetic resonance imaging (MRI), including structural MRI, functional MRI, and diffusion tensor imaging (DTI). Special tools developed are listed:
>> Large Deformation Diffeomorphic Metric Mapping (LDDMM) tools register images, landmark points, curves, and surface meshes.
>>The pipeline has several key components, structural delineation, segmentation denoising, surface momentum maps recording shape variation between anatomies
3. Random Field Analysis
4. Spatial Smoothing Functional Signals on the Cortex
5. Surface-based fMRI Analysis.