Biomechanics group interest is in the study of mechanics of biological systems and processes. Biomechanics is born from our attempt to understand and explain the natural phenomenon with engineering principles. There are two major divisions in biomechanics, namely the solid and the fluid. The latter encompasses the study of blood flow phenomenon and its interaction with the our biological systems, which include the in-depth understanding of the biochemical and pathophysiological processes of the major organs in our body, like the heart, lungs, kidney and liver.
The Cardiovascular Biomechanics and Ultrasound Laboratory focuses on two functionally related areas: 1) Pre-natal cardiovascular biomechanics; and 2) Medical Ultrasound Technology.
We are interested in investigating the role that mechanical forces play in normal foetal / embryonic development of the cardiovascular system, and the role that abnormal mechanical forces may play in causing congenital cardiovascular malformations. Our long term goal is to develop sufficient understanding of this relationship between mechanical forces and cardiovascular development to enable design of novel foetal surgical tools and techniques for the treatment of congenital anatomic malformations, as well as to enable novel pre-natal medicine to arrest pathological mechanobiology that leads to congenital defects. Foetal intervention holds the promise of tapping into the regenerative ability of foetuses for the treatment of congenital malformations.
Our second interest is in applying new ultrasound techniques for the evaluation and treatment of diseases. For example, we interested in elastography as an in vivo tool for evaluation of diseased tissues, and a combination of Doppler and computational techniques as an improved methods for evaluating adult heart valve diseases.
In the Computational Bioengineering Lab our mathematical/computational models can succinctly describe the a thousand (or more) experimental data points. Recently, there has been an explosion in the volume of biological data being recorded. It is becoming increasingly difficult to interpret these data, particularly if one is interested in combining multiple data sets together to understand the big picture. Computational Bioengineering, with its ability to describe data and concepts in terms of the universal language of mathematics, is gaining recognition as arguably the only viable solution to this problem. Our key focus areas are in Neurogastroenterology & Motility, and Cardiology. We are also focussed on the development of Computational Tools & Techniques to aid us in our work
The Integrated Microfluidic Biotechnology Laboratory at National University of Singapore focuses on developing integrated droplet-based microfluidic systems for performing bioassays in a high throughput manner. Using the advantages of an integrated microfluidic platform, millions of droplets are generated by a device, which can encapsulate active materials such as bio-molecules and single cells that can be digitally analyzed and sorted in a single chip. The power to screen large number of bio-reactions while using small sample amount offers the possibility to assay clinical samples for accurate diagnosis and to understand complex biological questions with unprecedented sensitivity and quantitation.
Microhemodynamics refers to the study of red blood cells flow in the microcirculation. Due to the close relationship between blood rheological properties and human cardiovascular diseases such as hypertension, atheroclerosis and stroke, our lab has carried out extensive and intensive research work on understanding the influence of altered blood rheological properties on important microcirculatory parameters seen in pathological conditions. In addition, we seek to develop novel measurement techniques to quantify blood rheological properties such as whole blood viscosity and red blood cell aggregation. Our ultimate engineering goal is to develop new clinical diagnostic devices for human diseases based on these new concepts.