^ Equal Contribution; * Corresponding Author

  1. Lim GS^, Hor JH^, Ho NRY, Wong CY, Ng SY, Soh BS*, Shao H*
    Microhexagon gradient array directs spatial diversification of spinal motor neurons.
    Theranostics, 9, 311-323 (2019).
  2. Chen Y, Ding X, Zhang Y, Natalia A, Sun X, Wang Z, Shao H*
    Design and synthesis of magnetic nanoparticles for biomedical diagnostics
    Quantitative Imaging in Medicine and Surgery, 8, 957 (2018). (Invited manuscript)
  3. Ho NRY^, Lim GS^, Sundah NR, Lim D, Loh TP, Shao H*
    Visual and modular detection of pathogen nucleic acids with enzyme-DNA molecular complexes.
    Nature Communications, 9, 3238 (2018).
    Featured as an Editors’ Highlight (
  4. Shao H, Im H, Castro CM, Breakefield XO, Weissleder R, Lee H
    New technologies for analysis of extracellular vesicles.
    Chemical Reviews, 118, 1817-1950 (2018).
  5. Wang L, Meng Z, Martina F, Shao H, Shao F
Fabrication of circular assemblies with DNA tetrahedrons: from static structures to a dynamic rotary motor.
    Nucleic Acids Research, 45, 12090-12099 (2017).
  6. Shao H*, Chung J, Issadore D
    Diagnostic technologies for circulating tumor cells and exosomes.
    Bioscience Reports, 36, e00292 (2016).
    (Invited manuscript)
  7. Shao H^, Chung J^, Lee K, Balaj L, Min C, Carter BS, Hochberg FH, Breakefield XO, Lee H, Weissleder R
    Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma.
    Nature Communications, 6, 6999 (2015).
    Featured as research highlight of the journal.
  8. Im H^, Castro CM^, Shao H, Liong M, Song J, Pathania D, Fexon L, Min C, Avila-Wallace M, Zurkiya O, Rho J, Magaoay B, Tambouret RH, Pivovarov M, Weissleder R, Lee H
    Digital diffraction analysis enables low-cost molecular diagnostics on a smartphone.
    Proc Natl Acad Sci USA, 122, 5613-5618 (2015).
  9. Im H, Shao H, Weissleder R, Castro CM, Lee H
    Nano-plasmonic exosome diagnostics.
    Expert Rev Mol Diagnostics, 15, 725-733 (2015).
  10. Lee K, Shao H, Weissleder R, Lee H
    Acoustic purification of extracellular microvesicles.
    ACS Nano, 9, 2321-2327 (2015).
  11. Im H^, Shao H^, Park Y, Peterson VM, Castro CM, Weissleder R, Lee H
    Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor.
    Nature Biotechnology, 32, 490-495 (2014).
    Featured as one of the greatest hits in 20 years of Nature Biotechnology biomedical research (
  12. Issadore D, Park Y, Shao H, Min C, Lee K, Liong M, Weissleder R, Lee H
    Magnetic sensing technology for molecular analyses.
    Lab on a Chip, 14, 2385-2397 (2014).
  13. Yoon TJ, Shao H, Weissleder R, Lee H
    Oxidation kinetics and magnetic properties of elemental iron nanoparticles.
    Part Part Syst Charact, 30, 667-671 (2013).
  14. Rho J, Chung J, Im H, Liong M, Shao H, Castro CM, Weissleder R, Lee H
    Magnetic nanosensor for detection and profiling of erthyrocyte-derived microvesicles.
    ACS Nano, 7, 11227-11233 (2013).
  15. Castro CM, Ghazani AA, Chung J, Shao H, Issadore D, Yoon TJ, Weissleder R, Lee H
    Miniaturized nuclear magnetic resonance platform for detection and profiling of circulating tumor cells.
    Lab on a Chip, 14, 14-23 (2013).
  16. Shao H, Chung J, Balaj L, Charest A, Bigner DD, Carter BS, Hochberg FH, Breakefield XO, Weissleder R, Lee H
    Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy.
    Nature Medicine, 18, 1835-1840 (2012).
    Featured by BBC News, recommended by Faculty of 1000, and research highlighted in:
    – Editors’ Choice: Warranted wiretapping: listening in on cancer’s conversations. Sci Transl Med 4, 164ed224 (2012).
    – Glioblastoma: microvesicles as major biomarkers. Nat Rev Cancer 13, 8 (2013).
    – Biomarkers: nanotechnology opens up new realm of detection in GBM. Nat Rev Clin Oncol 10, 4 (2013).
    – Glioblastoma detection and therapy monitoring by microvesicle release. Nat Rev Neurol 9, 4 (2013).
  17. Chung J^, Shao H^, Reiner T, Issadore D, Weissleder R, Lee H
    Cell sorting: microfluidic cell sorter (μFCS) for on-chip capture and analysis of single cells.
    Advanced Healthcare Materials, 1, 432-436 (2012).
    Featured as cover.
  18. Issadore D, Chung J^, Shao H^, Liong M, Ghazani AA, Castro CM, Weissleder R, Lee H Ultrasensitive clinical enumeration of rare cells ex vivo using a micro-hall detector.
    Science Translational Medicine, 4, 141ra92 (2012).
    Featured as cover.
  19. Min C, Shao H, Liong M, Yoon TJ, Weissleder R, Lee H
    Mechanism of magnetic relaxation switching sensing.
    ACS Nano, 6, 6821-6828 (2012).
  20. Shao H, Min C, Issadore D, Liong M, Yoon TJ, Weissleder R, Lee H
    Magnetic nanoparticles and microNMR for diagnostic applications.
    Theranostics, 2, 55-65 (2012).
  21. Yoon TJ^, Lee H^, Shao H, Hilderbrand SA, Weissleder R
    Multicore assemblies potentiate magnetic properties of biomagnetic nanoparticles.
    Advanced Materials, 23, 4793-4797 (2011).
  22. Yoon TJ^, Lee H^, Shao H, Weissleder R
    Highly magnetic core-shell nanoparticles with a unique magnetization mechanism.
    Angew Chem Int Ed Engl, 50, 4663-4666 (2011).
  23. Erathodiyil N, Gu H, Shao H, Jiang J, Ying JY
    Enantioselective hydrogenation of a-ketoesters over alkaloid-modified platinum nanowires.
    Green Chemistry, 13, 3070-3074 (2011).
  24. Mao J, Cao X, Zhen J, Shao H, Gu H, Lu J and Ying JY
    Facile synthesis of hybrid nanostructures from nanoparticles, nanorods and nanowires.
    Journal of Materials Chemistry, 21, 11478-11481 (2011).
  25. Shao H, Yoon TJ, Liong M, Weissleder R, Lee H
    Magnetic nanoparticles for biomedical NMR-based diagnostics.
    Beilstein Journal of Nanotechnology, 1, 142-154 (2010).
  26. Liong M, Shao H, Haun JB, Lee H, Weissleder R
    Carboxymethylated polyvinyl alcohol stabilizes doped ferrofluids for biological applications.
    Advanced Materials, 22, 5168-5172 (2010).
  27. Issadore D, Shao H, Chung J, Newton A, Pittet M, Weissleder R, Lee H
    Self-assembled magnetic filter for highly efficient immunomagnetic separation.
    Lab on a Chip, 11, 147-151 (2010).
  28. Jiang J, Gu H, Shao H, Devlin E, Papaefthymiou GC, Ying JY
    Bifunctional Fe
    3O4-Ag heterodimer nanoparticles for two-photon fluorescence imaging and magnetic manipulation.
    Advanced Materials, 20, 4403-4407 (2008).
  29. Zhao J, Wu J, Shao H, Kong F, Jain N, Hunt G, Feigenson GW
    Phase studies of model biomembranes: macroscopic coexistence of La and Lb, with light-induced coexistence of La + Lo phases.
    Biochim Biophys Acta, 1768, 2777-2786 (2007)